Linear Thermodynamics of Rodlike DNA Filtration

Linear thermodynamics transportation theory is employed to study filtration of rodlike DNA molecules. Using the repeated nanoarray consisting of alternate deep and shallow regions, it is demonstrated that the complex partitioning of rodlike DNA molecules of different lengths can be described by traditional transport theory with the configurational entropy properly quantified. Unlike most studies at mesoscopic level, this theory focuses on the macroscopic group behavior of DNA transportation. It is therefore easier to conduct validation analysis through comparison with experimental results. It is also promising in design and optimization of DNA filtration devices through computer simulation. Index Terms —DNA, Electrophoresis, Filtration. Entropy barrier, Transportation, Linear thermodynamics